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Calcium Atorvastatin bụ ihe na-egbochi HMG-CoA reductase yana uru IC50 nke 150 nM.
HMG-CoA reductase bụ isi enzyme nke ụzọ mevalonate nke na-emepụta cholesterol.HMG-CoA bụ enzyme na-ebelata ọnụego yana ọ dị mkpa maka ibelata ọkwa cholesterol ọbara.HMG-CoA reductase dị na endoplasmic reticulum ma nwee ngalaba transmembrane asatọ.Ndị na-egbochi HMG-CoA reductase nwere ike ime ka ndị na-anabata LDL (lipoprotein dị ala) dị na imeju.Ọ na-eduga n'ịbawanye ọkwa catabolism nke plasma LDL ma belata mkpokọta cholesterol plasma nke bụ ihe dị mkpa na-ekpebi atherosclerosis.HMG-CoA reductase na-arụ ọrụ dị mkpa na njikọ cholesterol.HMG-CoA bụ naanị ebumnuche maka ọgwụ na-ebelata cholesterol.HMG-CoA reductase bụkwa enzyme dị mkpa maka mmepe.Ọrụ nke HMG-CoA reductase nwere njikọ na ntụpọ mbugharị sel germ.Mgbochi nke ọrụ ya nwere ike ibute ọbara ọgbụgba intracerebral[1].
Atorvastatin bụ ihe mgbochi HMG-CoA reductase nwere uru IC50 nke 154 nM.Ọ dị irè n'ịgwọ ụfọdụ dyslipidemias na hypercholesterolemia[1].Ọgwụ Atorvastatin na 40 mg na-ebelata mkpokọta cholesterol 40% mgbe ụbọchị 40 gachara.A na-ejikwa ya na-agwọ ndị ọrịa akwara ọbara ma ọ bụ ọrịa strok nwere ọkwa cholesterol nkịtị.[2].Atorvastatin na-ebelata apheresis lipoproteins dị ala n'ime ndị ọrịa site na ime ka ndị na-anabata LDL.
A na-emegharị ya na ọtụtụ metabolites nke dị mkpa maka mmetụta nke omume ọgwụgwọ site na CYP3A4 (cytochrome P450 3A4).[3].
Ntụaka:
[1].van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: ịdị ogologo oge na nchekwa nke atorvastatin na ọgwụgwọ ụdị III siri ike yana dyslipidemia jikọtara ọnụ.Obi 2002, 88 (3): 234-238 .
[2].Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R. -nkezi mkpokọta cholesterol, na Anglo-Scandinavian Cardiac Excomes Trial--Lipid Lowering Arm (ASCOT-LLA): nnwale a na-achịkwa nke ọtụtụ etiti.Lancet 2003, 361 (9364): 1149-1158.
[3].Lennernas H: ọgwụ pharmacokinetics nke atorvastatin.Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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