ndabere

Calcium Atorvastatin bụ ihe na-egbochi HMG-CoA reductase yana uru IC50 nke 150 nM.
HMG-CoA reductase bụ isi enzyme nke ụzọ mevalonate nke na-emepụta cholesterol. HMG-CoA bụ enzyme na-egbochi ọnụego yana ọ dị mkpa maka iweda ọkwa cholesterol ọbara. HMG-CoA reductase dị na endoplasmic reticulum ma nwee ngalaba transmembrane asatọ. Ndị na-egbochi HMG-CoA reductase nwere ike ime ka ndị na-anabata LDL (lipoprotein dị ala) dị na imeju. Ọ na-eduga n'ịbawanye ọkwa catabolism nke plasma LDL ma belata mkpokọta cholesterol plasma nke bụ ihe dị mkpa na-ekpebi atherosclerosis. HMG-CoA reductase na-arụ ọrụ dị mkpa na njikọ cholesterol. HMG-CoA bụ naanị ebumnuche maka ọgwụ na-ebelata cholesterol. HMG-CoA reductase bụkwa enzyme dị mkpa maka mmepe. Ọrụ nke HMG-CoA reductase nwere njikọ na ntụpọ mbugharị sel germ. Mgbochi nke ọrụ ya nwere ike ibute ọbara ọgbụgba intracerebral[1].
Atorvastatin bụ ihe mgbochi HMG-CoA reductase nwere uru IC50 nke 154 nM. Ọ dị irè n'ịgwọ ụfọdụ dyslipidemias na hypercholesterolemia[1]. Ọgwụ Atorvastatin na 40 mg na-ebelata mkpokọta cholesterol 40% mgbe ụbọchị 40 gachara. A na-ejikwa ya agwọ ndị ọrịa akwara ọbara ma ọ bụ ọrịa strok nwere ọkwa cholesterol nkịtị.[2] Atorvastatin na-ebelata apheresis lipoproteins dị ala n'ime ndị ọrịa site na ime ka ndị na-anabata LDL.
A na-emegharị ya na ọtụtụ metabolites nke dị mkpa maka mmetụta nke omume ọgwụgwọ site na CYP3A4 (cytochrome P450 3A4).[3].
Ntụaka:
[1]. van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: ịdị ogologo oge na nchekwa nke atorvastatin na ọgwụgwọ nke ụdị III siri ike yana dyslipidemia jikọtara ọnụ. Obi 2002, 88 (3): 234-238 .
[2]. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R. -nkezi mkpokọta cholesterol, n'ime Anglo-Scandinavian Cardiac Ọnwụnwa - Mbelata Lipid. (ASCOT-LLA): nnwale a na-achịkwa n'ọtụtụ ebe. Lancet 2003, 361 (9364): 1149-1158.
[3]. Lennernas H: ọgwụ pharmacokinetics nke atorvastatin. Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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