Nkọwa

Hydrochlorothiazide (HCTZ), ọgwụ diuretic na-arụ ọrụ ọnụ nke klas thiazide, na-egbochi mgbanwe TGF-β/Smad ụzọ akara. Hydrochlorothiazide nwere mmetụta ntụrụndụ vaskụla ozugbo site na imeghe ọwa potassium na-arụ ọrụ calcium (KCA). Hydrochlorothiazide na-eme ka ọrụ obi dịkwuo mma, na-ebelata fibrosis ma nwee mmetụta antihypertensive.

ndabere

Hydrochlorothiazide bụ ọgwụ diuretic nke klas thiazide.

Na Vitro

Hydrochlorothiazide bụ nke thiazide klas nke diuretics. Ọ na-ebelata oke ọbara site na ime akụrụ iji belata nnabata sodium (Na) na tubule gbagọrọ agbagọ. Ebe kachasị arụ ọrụ na nephron na-apụta na onye na-ebugharị electroneutral Na+-Cl site na ịsọ mpi maka saịtị chloride na onye na-ebufe ya. Site n'imebi njem ụgbọ njem na tubule gbagọrọ agbagọ, hydrochlorothiazide na-ebute natriuresis na mfu mmiri na-eso ya. Thiazides na-abawanye nnabata nke calcium na mpaghara a n'ụzọ na-enweghị njikọ na njem sodium. Na mgbakwunye, site na usoro ndị ọzọ, Hydrochlorothiazide kwenyere na ọ na-ebelata nguzogide vaskụla mpụta.

Hydrochlorothiazide (HCTZ; ọnụ sitegavage; 12.5 mg/kg/d; 8 izu) emewo ka mma obi ọrụ, mbelata obi interstitial fibrosis nke obi na collagen olu ntakiri, mbelata okwu AT1, TGF-β na Smad2 na akwara obi na oke oke Sprague Dawley. Na mgbakwunye, hydrochlorothiazide na-ebelata ọkwa plasma angiotensin II na aldosterone. Ọzọkwa, hydrochlorothiazide na-egbochi angiotensin II na-ebute TGF-β1 na okwu protein Smad2 na fibroblasts ventricular rat nwa ọhụrụ.

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