Abrocitinib
Abrocitinib bụ ọnụ, obere molecule, Janus kinase (JAK) 1 inhibitor na mmepe maka ọgwụgwọ ndị okenye na ndị nọ n'afọ iri na ụma nwere oke atopic dermatitis.
A na-enyocha Abrocitinib na nyocha ụlọ ọgwụ NCT03796676 (JAK1 Inhibitor With Medicated Topical Therapy in Adolescent with Atopic Dermatitis).
Pfizer na-emepụta Abrocitinib ugbu a maka ọgwụgwọ atopic dermatitis (eczema).Ọ bụ onye na-egbochi Janus kinase 1 (JAK1) otu ugboro kwa ụbọchị nyocha.
Atopic dermatitis (AD) bụ mgbagwoju anya, nke na-adịghị ala ala, ọrịa akpụkpọ ahụ na-egbuke egbuke nke e ji itching, oké itching, na eczematous ọnya na-emetụta ihe dịka 25% ụmụaka na 2% ruo 3% nke ndị okenye n'ụwa nile.Abrocitinib bụ onye na-emechi emechi nke Janus kinase-1 (JAK1) enzyme na-egbochi usoro mkpali.Ya mere, anyị bu n'obi iji nyochaa ịdị irè na nchekwa nke abrocitinib maka AD na-agafeghị oke na nke siri ike.
Abrocitinib na dose 100 mg ma ọ bụ 200 mg bụ ọgwụ dị irè, nke anabatara nke ọma na nke na-ekwe nkwa n'ịgwọ ndị ọrịa nwere oke atopic dermatitis.Otú ọ dị, nyocha ahụ kwadoro ịdị irè nke abrocitinib 200 mg karịa 100 mg, ma mmetụta ndị dị ka ọgbụgbọ na isi ọwụwa nwere ike ime karịa na 200 mg.
Atụmatụ18Ọrụ nlebanya na-agbanwe agbanwe nke akwadoro4, na6A na-akwado ọrụ ngo.
Usoro njikwa ogo mba ụwa dị elu etinyela ntọala siri ike maka ire ahịa.
Nlekọta dị mma na-aga n'ihu na usoro ndụ nke ngwaahịa ahụ niile iji hụ na ịdịmma na mmetụta ọgwụgwọ.
Ndị otu Regulatory Affairs ndị ọkachamara na-akwado ịdịmma chọrọ n'oge ngwa na ndebanye aha.