Agomelatine
ndabere
Agomelatine bụ agonist nke ndị na-anabata melatonin na onye na-emegide 5-HT2C na-anabata serotonin nwere ụkpụrụ Ki nke 0.062nM na 0.268nM na IC50 uru nke 0.27μM, n'otu n'otu maka MT1, MT2 na 5-HT2C [1].
Agomelatine bụ ọgwụ mgbochi ịda mbà n'obi pụrụ iche ma mepụta ya maka ọgwụgwọ nke nnukwu ịda mbà n'obi (MDD).Agomelatine na-ahọrọ megide 5-HT2C.Ọ na-egosi njikọ dị ala na mmadụ 5-HT2A na 5-HT1A.Maka ndị na-anabata melatonin, agomelatine na-egosi ụdị mmekọ ahụ na mmadụ MT1 na MT2 nwere ụkpụrụ Ki nke 0.09nM na 0.263nM, n'otu n'otu.N'ime ọmụmụ vivo, agomelatine na-ebute mmụba nke dopamine na ọkwa noradrenaline site na igbochi ntinye ihe mgbochi nke 5-HT2C.Ọzọkwa, nchịkwa nke agomelatine na-egbochi mbelata nchekasị na-akpata mbelata oriri sucrose n'ụdị oke ịda mbà n'obi.Na mgbakwunye na nke ahụ, agomelatine na-eme ka ọ dị mma na-ebelata nchekasị n'ụdị oke ụjọ [1].
Ntụaka:
[1] Zupancic M, Guilleminault C. Agomelatine.ọgwụ CNS, 2006, 20 (12): 981-992.
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