Agomelatine
ndabere
Agomelatine bụ agonist nke ndị na-anabata melatonin na onye na-emegide 5-HT2C na-anabata serotonin nwere ụkpụrụ Ki nke 0.062nM na 0.268nM na IC50 uru nke 0.27μM, n'otu n'otu maka MT1, MT2 na 5-HT2C [1].
Agomelatine bụ ọgwụ mgbochi ịda mbà n'obi pụrụ iche ma mepụta ya maka ọgwụgwọ nke nnukwu ịda mbà n'obi (MDD). Agomelatine na-ahọrọ megide 5-HT2C. Ọ na-egosi njikọ dị ala na mmadụ 5-HT2A na 5-HT1A. Maka ndị na-anabata melatonin, agomelatine na-egosi ụdị mmekọ ahụ na mmadụ MT1 na MT2 nwere ụkpụrụ Ki nke 0.09nM na 0.263nM, n'otu n'otu. N'ime ọmụmụ vivo, agomelatine na-ebute mmụba nke dopamine na ọkwa noradrenaline site na igbochi ntinye ihe mgbochi nke 5-HT2C. Ọzọkwa, nchịkwa nke agomelatine na-egbochi mbelata nchekasị na-akpata mbelata oriri sucrose n'ụdị oke ịda mbà n'obi. E wezụga nke ahụ, agomelatine na-eme ka ọ kwụsịlata mmetụta nchegbu n'ụdị oke nchegbu [1].
Ntụaka:
[1] Zupancic M, Guilleminault C. Agomelatine. ọgwụ CNS, 2006, 20 (12): 981-992.
Ọdịdị chemical
Atụmatụ18Arụmọrụ ntule na-agbanwe agbanwe nke akwadoro4, na6oru ngo na-akwado.
Usoro njikwa ogo mba ụwa dị elu etinyela ntọala siri ike maka ire ahịa.
Nlekọta dị mma na-aga n'ihu na usoro ndụ nke ngwaahịa ahụ niile iji hụ na ịdị mma na mmetụta ọgwụgwọ.
Ndị otu Regulatory Affairs ndị ọkachamara na-akwado ịdịmma chọrọ n'oge ngwa na ndebanye aha.
Ahịrị nkwakọ ngwaahịa Korea Countec
Taiwan CVC ahịrị nkwakọ ngwaahịa
Line CAM Board nke Italy
Igwe na-agbakọ Fette German
Ihe nchọpụta mbadamba ihe ngosi nke Japan
Ụlọ njikwa DCS
