China Bictegravir 1611493-60-7 ndị na-emepụta na ndị na-eweta ngwaahịa

Bictegravir 1611493-60-7

Nkọwa dị mkpirikpi:

Aha API	Ngosipụta	Onye mmepụta ihe	Ụbọchị Mmebi Ikikere (US)
Bictegravir 1611493-60-7	Ọrịa HIV-1	Sayensị Gilead	Ọnwa Iri na Abụọ 19, 2033

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Bictegravir bụ akwụkwọ akụkọ, onye na-egbochi nje HIV-1 na IC50 nke 7.5 nM.

Na Vitro

Bictegravir (BIC) na-egbochi ọrụ mbufe eriri na IC50 nke 7.5± 0.3 nM. N'ihe metụtara mgbochi ya nke ọrụ mbufe strand, Bictegravir bụ ihe na-egbochi ike nke 3.'-Nhazi ọrụ nke HIV-1 IN, yana IC50 nke 241±51 nM. Bictegravir na-eme ka mkpokọta 2-LTR dị gburugburu ~ 5-n'ụzọ metụtara njikwa a na-akwa emo ma na-ebelata ọnụ ọgụgụ nke ngwaahịa njikọta nke ọma na sel ndị butere site na 100 okpukpu. Bictegravir na-egbochi nje HIV-1 nke ọma na mkpụrụ ndụ MT-2 na MT-4 nwere EC50s nke 1.5 na 2.4 nM, n'otu n'otu. Bictegravir na-egosipụta mmetụta antiviral siri ike na CD4+ T lymphocytes bụ isi na macrophages nke monocyte enwetara, yana EC50s nke 1.5.±0.3 nM na 6.6±4.1 nM, n'otu n'otu, nke tụnyere ụkpụrụ enwetara n'ahịrị T-cell[1].

MCE akwadobeghị izi ezi nke ụzọ ndị a. Ha bụ naanị maka ntụnye aka.

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NCT03998176	Mahadum Nebraska \| Gilead Sciences	HIV-1 - ọrịa	Ọktoba 9, 2019	Agba 4
NCT03789968	Thomas Jefferson University \| Mahadum Maryland, College Park \| Health University Indiana \| Ụlọ Ọgwụ Ụlọ Ọgwụ Brooklyn \| Mahadum Illinois na Chicago \| Mahadum Nova Southeast \| Mahadum California, San Francisco	HIV + AIDS	Septemba 1, 2019
NCT04249037	Mahadum Colorado, Denver \| Gilead Sciences	HIV + AIDS	Maachị 1, 2020	Ọ metụtaghị
NCT04132674	Ụlọ Ọrụ Ọrịa na-efe efe nke Vancouver	Nje Virus Immunodeficiency mmadụ nke mbụ \| Ojiji ọgwụ	Nọvemba 26, 2018	Agba 4
NCT04054089	Cristina Mussini \| Mahadum nke Modena na Reggio Emilia	Ọrịa HIV	Septemba 2019	Agba 4
NCT04155554	Azienda Ospedaliera Universitaria Senese\|Katọlik University of the Sacred Heart\|Ospedale Policlinico San Martino\|Azienda Ospedaliera San Paolo\|Ospedale Amedeo di Savoia	HIV-1 - ọrịa	Jenụwarị 29, 2020	Nkeji 3
NCT02275065	Sayensị Gilead	Ọrịa HIV-1	Ọktoba 2014	Agba 1
NCT03711253	Mahadum Southern California	Ọrịa HIV dị oke njọ	Ọktoba 14, 2019	Agba 4
NCT02400307	Sayensị Gilead	HIV	Eprel 17, 2015	Agba 1
NCT03499483	Fenway Community Health	Mgbochi HIV	Jenụwarị 24, 2019	Agba 4
NCT03502005	Midland Research Group, Inc.\|Gilead Sciences	Nje Virus Immunodeficiency nke mmadụ	Maachị 1, 2018	Agba 4