Nkọwa

Bictegravir bụ akwụkwọ akụkọ, onye na-egbochi nje HIV-1 na IC50 nke 7.5 nM.

Na Vitro

Bictegravir (BIC) na-egbochi ọrụ mbufe eriri na IC50 nke 7.5± 0.3 nM.N'ihe metụtara mgbochi ya nke ọrụ mbufe strand, Bictegravir bụ ihe na-egbochi ike nke 3.'-Nhazi ọrụ nke HIV-1 IN, yana IC50 nke 241±51 nM.Bictegravir na-eme ka mkpokọta 2-LTR dị gburugburu ~ 5-n'ụzọ kwekọrọ na njikwa a na-akwa emo ma na-ebelata ọnụ ọgụgụ nke ngwaahịa njikọta na sel ndị butere site na 100 okpukpu.Bictegravir na-egbochi nje HIV-1 nke ọma na mkpụrụ ndụ MT-2 na MT-4 nwere EC50s nke 1.5 na 2.4 nM, n'otu n'otu.Bictegravir na-egosipụta mmetụta antiviral siri ike na CD4 + T lymphocytes bụ isi na macrophages nke monocyte enwetara, yana EC50s nke 1.5.±0.3 nM na 6.6±4.1 nM, n'otu n'otu, nke tụnyere ụkpụrụ enwetara n'ahịrị T-cell[1].

MCE akwadobeghị izi ezi nke ụzọ ndị a n'onwe ya.Ha bụ naanị maka ntụnye aka.

Ọdịdị chemical