Crisaborole

Nkọwa dị mkpirikpi:

Aha API Ngosipụta Onye mmepụta ihe Ụbọchị Mmebi Ikikere (US)
Crisaborole Atopic dermatitis na eczema Pfizer Ọnwa Isii 11, 2026 


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Nkọwa ngwaahịa

Crisaborole bụ onye otu klas nke benzoxaboroles nke bụ 5-hydroxy-1,3-dihydro-2,1-benzoxaborole nke phenolic.hydrogene jiriwo otu 4-cyanophenyl dochie ya.A phosphodiesterase 4 inhibitor nke a na-eji maka ọgwụgwọ atopic dermatitis dị nro ma na-agafeghị oke na ụmụaka na ndị okenye.Ọ nwere ọrụ dị ka phosphodiesterase IV inhibitor, anantipsoriaticna ọgwụ mgbochi mkpali na-abụghị steroidal.Ọ bụ benzoxaborole, ether aromatic na nitrile.

Crisaborole bụ akwụkwọ akụkọoxaboroleFDA kwadoro na Disemba 14, 2016 dị ka Eucrisa, ọgwụgwọ n'elu maka dermatitis dị nro ma na-agafeghị oke.Onye na-abụghị steroidal a na-arụ ọrụ nke ọma n'ịkwalite oke ọrịa, na-ebelata ihe ize ndụ nke ibute ọrịa na ibelata akara na mgbaàmà na ndị ọrịa 2 afọ na karịa.Ọ na-ebelata mbufụt mpaghara na akpụkpọ ahụ ma gbochie ọrịa ahụ na-emewanyewanye nke ọma na profaịlụ nchekwa dị mma.Ọdịdị ya nwere aboronatom, nke na-eme ka ntinye anụ ahụ dị mfe ma na-ejikọta ya na etiti bimetal nke phosphodiesterase 4 enzyme.A na-emepe ya ugbu a dị ka ọgwụgwọ psoriasis n'elu.

Crisaborole bụ ihe mgbochi phosphodiesterase 4.Usoro nke crisaborole na-eme ihe dị ka ihe mgbochi phosphodiesterase 4.

Asambodo

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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