ndabere

Canagliflozin bụ akwụkwọ akụkọ, dị ike na onye na-ebugharị sodium glucose co-transporter (SGLT) 2 inhibitor [1].E gosiputara na Canagliflozin nwere ike ịbawanye mmịpụta glucose mmamịrị site na ibelata ọnụ ụzọ glukos nke gbasara akụrụ yana ibelata nnabata nnabata glucose nzacha [2].

E gosiputara Canagliflozin ka ọ gbochie oriri Na + -mediated 14C-AMG na CHO-hSGLT2, CHO-rat SGLT2 na CHO-mouse SGLT2 nwere ụkpụrụ IC50 nke 4.4, 3.7 na 2.0 nM, n'otu n'otu.

A kọwo na Canagliflozin na-ebelata ọkwa glucose ọbara (BG) dabere na ma db/db ụmụ oke na oke abụba na-arịa ọrịa shuga Zucker (ZDF).Na mgbakwunye, canagliflozin egosila na ọ na-ebelata oke mgbanwe iku ume, yana ịdị arọ ahụ na oke DIO na oke ZDF [1].

Canagliflozin nwere ike were ọnụ [1].

Ntụaka:
[1] Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Mmetụta nke canagliflozin na ọnụ ụzọ akụrụ. maka glucose, glycemia, na arọ ahụ n'ụdị anụmanụ nkịtị yana ọrịa shuga.PLoS Otu.2012;7 (2): e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), onye nnọchi anya ọnụ ọgụgụ akwụkwọ akụkọ maka ụdị ọrịa shuga 2.P T. 2013 Nov; 38 (11): 656-66

Ndepụta ngwaahịa

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al."Usoro mkpebi dị iche iche maka njikwa nke ụdị ihe dị iche iche: Ngwa maka mkpebi nke ọgwụ hypoglycemic emekọbara ọhụrụ n'ụdị usoro ọgwụgwọ ọgwụ jikọtara ọnụ."Spectrochimica Acta Nkebi A: Molecular na Biomolecular Spectroscopy Dị na ntanetị 20 June 2018.

Ọdịdị chemical