Daclatasvir Dihydrochloride
Nkọwa
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) bụ ihe dị ike ma na-arụ ọrụ ọnụ.HCV NS5A proteininhibitor naEC50s nso nke 9-146 pM makaọtụtụ HCV replicon genotypes.Daclatasvir dihydrochloride bụkwa aorganic anion na-ebu polypeptide 1B (OATP1B)naOATP1B3inhibitor naIC50s nke 1.5 µM na 3.27 µM, n'otu n'otu.
IC50& Ebumnuche
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) na 3 pM. HCV replicon genotype 5a)[1]
Kd: 8 nM (NS5A33-202) na 210 nM (NS5A26-202)[2]
IC50: 1.5µM (OATP1B) na 3.27 µM (OATP1B3)[3]
Na Vitro
Daclatasvir (BMS-790052) na-egosipụta ọrụ mgbochi siri ike n'akụkụ ụdị genotypes niile nwalere, yana EC.50ụkpụrụ sitere na 9 pM ruo 146 pM.Daclatasvir na-egbochi HCV replicon genotype 1a, 1b, 2a, 3a, 4a and 5a with EC50ụkpụrụ nke 50 pM, 9 pM, 71 pM, 146 pM, 12 pM na 33 pM, n'otu n'otu.Daclatasvir bụ onye na-egbochi nje na-efe efe nke JFH-1 genotype 2a nke na-emegharị na omenala cell (EC).50=28 pm)[1].Daclatasvir (BMS-790052) na-ejikọta ya na NS5A33-202 na NS5A26-202 na K.ds nke 8 nM na 210 nM, n'otu n'otu[2].
Nchekwa
| Ntụ ntụ | -20°C | Afọ 3 |
| 4°C | afọ 2 | |
| Na ihe mgbaze | -80 Celsius | Ọnwa isii |
| -20°C | 1 ọnwa |
Ọnwụnwa ụlọọgwụ
| Nọmba NCT | Onye nkwado | Ọnọdụ | Ụbọchị mmalite | Usoro |
| NCT03369327 | Tehran University of Medical Sciences|Rojan Pharma Pharmaceutical Company | Ọrịa ịba ọcha n'anya C, Nzaghachi na ọgwụgwọ nke | Nje Virus Immunodeficiency mmadụ | Ọnwa Mbụ 1, 2017 | Nkeji 3 |
| NCT03485846 | R-Pharm | Almedis | Ịba ọcha n'anya C Genotype 1b | Nọvemba 27, 2017 | Agba 2 |
| NCT01016912 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Disemba 2009 | Agba 2 |
| NCT01629732 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Maachị 2013 | Agba 2 |
| NCT01497834 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Jenụwarị 2012 | Nkeji 3 |
| NCT01973049 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Disemba 2013 | Nkeji 3 |
| NCT00663208 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Mee 2008 | Agba 2 |
| NCT02576314 | Ebe nyocha gbasara ahụike mmadụ na ahụike | ụlọ ọgwụ Beijing 302 | Ọrịa ịba ọcha n'anya C na-adịghị ala ala | Mee 2015 | Nkeji 3 |
| NCT02756936 | Ezigbo ebe nyocha, Egypt | Zeta Pharma Pharmaceutical Industries | Ahụ ike | Febụwarị 2016 | Agba 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute | Mahadum Cairo | Ịba ọcha n'anya C, Na-adịghị ala ala|Hepatocellular Carcinoma | Maachị 2016 | Nkeji 3 |
| NCT03706898 | Viriom | HIV-1-ọrịa | Mmebi imeju | Ọktoba 1, 2018 | Agba 1 |
| NCT02319031 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Febụwarị 2015 | Nkeji 3 |
| NCT02124044 | National Institutes of Health Clinical Center (CC)|National Institute of Allergy and Diseases (NIAID)|Bristol-Myers Squibb | HIV-HCV | Febụwarị 2014 | Agba 2 |
| NCT02551861 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Disemba 2015 | Agba 2 |
| NCT00859053 | Bristol-Myers Squibb | Enweghi ike imeju | Maachị 2009 | Agba 1 |
| NCT01257204 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Disemba 2010 | Agba 2 |
| NCT03063879 | Tehran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Hamadan University of Medical Sciences | Ịba ọcha n'anya C, Na-adịghị ala ala|Ụdị gbasara gbasara akụrụ na-adịghị ala ala | Eprel 1, 2017 | Agba 4 |
| NCT01017575 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Disemba 2009 | Agba 2 |
| NCT02865369 | Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Ịba ọcha n'anya C | Septemba 2016 |
|
| NCT04070235 | Ụgwọ nke ụlọ ọrụ Nanjing Sanhome Pharmaceutical Co., Ltd. | Ịba ọcha n'anya C, na-adịghị ala ala | Maachị 29, 2019 | Agba 2 | Nkeji 3 |
| NCT03487848 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Ịba ọcha n'anya | Mee 18, 2018 | Agba 2 |
| NCT00904059 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Mee 2009 | Agba 1 |
| NCT02107365 | Ụlọ ọrụ National Institute for Health and Medical Research-France National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C Virus Genotype 4 | Nọvemba 2013 | Agba 2 |
| NCT02397395 | Janssen R&D Ireland | Mmebi gbasara gbasara akụrụ|Ọrịa gbasara gbasara akụrụ ngwụcha | Mee 2015 | Agba 2 |
| NCT03169348 | Mahadum Assiut | Ịba ọcha n'anya C | Nọvemba 1, 2017 | Ọ metụtaghị |
| NCT02323594 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Disemba 2014 | Agba 1 |
| NCT03537196 | Ụlọ ọrụ mba France maka nyocha ahụike na ahụike-Ụlọ ọrụ mba France maka nyocha AIDS na ịba ọcha n'anya (Inserm-ANRS) | Ịba ọcha n'anya C | Iji ọgwụ eme ihe | Ọrịa ịba ọcha n'anya C | Nọvemba 13, 2018 | Agba 4 |
| NCT02103569 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Eprel 2014 | Agba 1 |
| NCT02772744 | Mahadum Zagazig | Mahadum Cairo | Ịba ọcha n'anya C | Nọvemba 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Jenụwarị 2013 | Nkeji 3 |
| NCT02496078 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Ọgọst 2015 | Nkeji 3 |
| NCT01425970 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Mee 2012 | Agba 2 |
| NCT01471574 | Bristol-Myers Squibb | Ịba ọcha n'anya C, Genotype 1 | Disemba 2011 | Nkeji 3 |
| NCT01573351 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Mee 2012 | Nkeji 3 |
| NCT01938625 | Janssen R&D Ireland | Ịba ọcha n'anya C, na-adịghị ala ala | Disemba 12, 2013 | Agba 2 |
| NCT01492426 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Jenụwarị 2012 | Nkeji 3 |
| NCT03480932 | Johns Hopkins Bloomberg School of Health Public|National Institute on Drug Abuse (NIDA)|YR Gaitonde Center for AIDS Research and Education | Ịba ọcha n'anya C, na-adịghị ala ala | Febụwarị 2, 2018 | Agba 2 | Nkeji 3 |
| NCT03163849 | Mahadum Assiut | Ịba ọcha n'anya c | Septemba 1, 2019 | Nkeji 3 |
| NCT01581203 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Mee 2012 | Nkeji 3 |
| NCT01492504 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Febụwarị 7, 2012 |
|
| NCT03686722 | Mohamed Raslan | Mahadum Ain Shams | Ebe nyocha ọgwụ ọgwụ, Cairo, Egypt | Ọrịa shuga mellitus, ụdị 2 | ịba ọcha n'anya C | Mmekọrịta ọgwụ | Septemba 9, 2017 | Agba 1 |
| NCT02262728 | Janssen Research & Development, LLC | Ịba ọcha n'anya C, na-adịghị ala ala | Septemba 30, 2014 | Agba 2 |
| NCT02349048 | Janssen Research & Development, LLC | Ọrịa ịba ọcha n'anya C | Jenụwarị 2015 | Agba 2 |
| NCT03882307 | Mahadum Assiut | Ịba ọcha n'anya C, na-adịghị ala ala | Mee 2020 | Agba mbụ 1 |
| NCT02758509 | Parc de Salut Mar | Ịba ọcha n'anya C | Cirrhosis | Ọnwa Mbụ 1, 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Maachị 2013 | Agba 2 |
| NCT03549832 | Mahadum Assiut | Mahadum Sohag | Mahadum South Valley | HCV Coinfection | Ọnwa Mbụ 1, 2018 | Ọ metụtaghị |
| NCT02161939 | Bristol-Myers Squibb | Ịba ọcha n'anya C |
| |
| NCT01309932 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Maachị 2011 | Agba 2 |
| NCT01995266 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Ọnwa Abụọ 28, 2014 | Nkeji 3 |
| NCT02640157 | AbbVie | Ịba ọcha n'anya C | Ọrịa ịba ọcha n'anya C | Nje Virus Genotype 3 Hepatitis C | Disemba 2015 | Nkeji 3 |
| NCT02032875 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Maachị 2014 | Nkeji 3 |
| NCT02624063 | Mahadum Federal nke Sao Paulo | Ịba ọcha n'anya C, na-adịghị ala ala | Disemba 2015 | Agba 4 |
| NCT00546715 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Nọvemba 2007 | Agba 1 | Nkeji 2 |
| NCT01718145 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Nọvemba 2012 | Nkeji 3 |
| NCT01616524 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C (HCV) | Julaị 2012 | Nkeji 3 |
| NCT02032901 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Jenụwarị 2014 | Nkeji 3 |
| NCT03540212 | Mahadum Ain Shams | Ọrịa HCV na-adịghị ala ala | Disemba 10, 2017 | Agba 2 | Nkeji 3 |
| NCT02097966 | Bristol-Myers Squibb | Ịba ọcha n'anya C |
| |
| NCT02596880 | Tehran University of Medical Sciences | Ịba ọcha n'anya C | Cirrhosis | Septemba 2015 | Nkeji 3 |
| NCT04019717 | Akụkọ ihe mere eme nke Atea Pharmaceuticals, Inc. | Ịba ọcha n'anya C | Ịba ọcha n'anya C, Chronic | Ịba ọcha n'anya C | Ọrịa ịba ọcha n'anya C | Ọnwa Isii 20, 2019 | Agba 2 |
| NCT02992457 | Mahadum Tanta | Ịba ọcha n'anya C | Jenụwarị 2015 | Agba 4 |
| NCT03547895 | Mahadum Zagazig | Cirrhosis decompensated | Ọnwa Isii 1, 2015 | Ọ metụtaghị |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Ịba ọcha n'anya C | Nọvemba 2016 | Nkeji 3 |
| NCT01051414 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Eprel 2010 | Agba 2 |
| NCT02309450 | Ụlọ ọrụ National Institute for Health and Medical Research-France National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C Virus Genotype 4 | Disemba 2014 | Agba 2 |
| NCT01628692 | Bristol-Myers Squibb | Janssen Research & Development, LLC | Ọrịa ịba ọcha n'anya C | Julaị 2012 | Agba 2 |
| NCT03186313 | Hospitallọ ọgwụ imeju Egypt | ụlọ ọgwụ Wadi El Nil | Ịba ọcha n'anya C | Septemba 2016 | Nkeji 3 |
| NCT03063723 | Ụlọ ọgwụ mmekọ nke atọ, Mahadum Sun Yat-Sen | Ịba ọcha n'anya C (Ọgba aghara) | Ọnwa Mbụ 1, 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Ọktoba 2009 | Agba 1 |
| NCT01725542 | Ụlọ ọrụ National Institute for Health and Medical Research-France National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Njikọ Ọrịa HCV-HIV | Disemba 2012 | Agba 2 |
| NCT02282709 | Ntọala maka nyocha imeju | Ịba ọcha n'anya C | Febụwarị 2014 | Nkeji 3 |
| NCT02032888 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Febụwarị 2014 | Nkeji 3 |
| NCT03247296 | Mahadum MTI | Ịba ọcha n'anya C | Ọnwa Abụọ 28, 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Septemba 2011 | Nkeji 3 |
| NCT02556086 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Disemba 2015 | Agba 2 |
| NCT01741545 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Ọnwa Atọ 31, 2013 | Nkeji 3 |
| NCT01866930 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C na-adịghị ala ala | Ọnwa Asaa 11, 2013 | Nkeji 3 |
| NCT02268864 | Ụgwọ nke ụlọ ọrụ Janssen-Cilag International N.V | Ịba ọcha n'anya C, na-adịghị ala ala | Jenụwarị 2015 | Agba 2 |
| NCT01797848 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Ọnwa Isii 2014 | Nkeji 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah | Mahadum Assiut | Ịba ọcha n'anya C | June 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Ọnwa Isii 2014 | Agba 1 |
| NCT01125189 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Julaị 2010 | Agba 2 |
| NCT03748745 | Ụgwọ nke ụlọ ọrụ Nanjing Sanhome Pharmaceutical Co., Ltd. | Mmekọrịta ọgwụ | Nọvemba 19, 2018 | Agba 1 |
| NCT01012895 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Disemba 2009 | Agba 2 |
| NCT02565888 | Mahadum Radboud | Ịba ọcha n'anya C | HIV | Nọvemba 2015 | Agba 1 |
| NCT02555943 | Humanity na Health Research Center|Beijing 302 Hospital|Nanfang Hospital nke Southern Medical University | Ọrịa ịba ọcha n'anya C na-adịghị ala ala|HBV Coinfection|Mweghachi ịba ọcha n'anya B | Febụwarị 2015 | Agba 2 | Nkeji 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF | South California Research Center | Ịba ọcha n'anya C | Cirrhosis | Jenụwarị 2015 | Agba 4 |
| NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Saint Vincent's Hospital, Korea|Konkuk University Hospital|Cheongju St. Mary's Hospital, Cheongju , Korea|Ụlọ Ọgwụ Severance|Ụlọ Ọgwụ Guro University Korea|Ụlọ Ọgwụ Eulji General|Mahadum Katọlik nke Korea | Ịba ọcha n'anya C | Febụwarị 2016 | Agba 4 |
| NCT02104843 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Eprel 2014 | Agba 1 |
| NCT01428063 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Septemba 2011 | Agba 2 |
| NCT02123654 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Eprel 2014 | Nkeji 3 |
| NCT02565862 | Mahadum Radboud | Ịba ọcha n'anya C | Ọrịa shuga mellitus | Nguzogide insulin | Jenụwarị 2016 | Agba 1 |
| NCT04211844 | Mahadum Ain Shams | Ịba ọcha n'anya C | Ọktoba 1, 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Ọnwa Isii 2009 | Agba 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | Akụrụ ada, Na-adịghị ala ala|Hepatitis C | Maachị 15, 2019 | Nkeji 3 |
| NCT01448044 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Disemba 2011 | Nkeji 3 |
| NCT01359644 | Bristol-Myers Squibb | Ụlọ ahịa ọgwụ | Ịba ọcha n'anya C | June 2011 | Agba 2 |
| NCT01842451 | Ụgwọ nke ụlọ ọrụ Vertex Pharmaceuticals Incorporated | Ịba ọcha n'anya C|CHC|HCV|Ịba ọcha n'anya C | Ọnwa Isii 2013 | Agba 2 |
| NCT02762448 | Ụlọ ọgwụ Tainan Municipal | Ịba ọcha n'anya c | Julaị 2016 |
|
| NCT02473211 | Ebe nyocha gbasara ahụike mmadụ na ahụike | ụlọ ọgwụ Beijing 302 | Ọrịa ịba ọcha n'anya C na-adịghị ala ala | Jenụwarị 2015 | Agba 2 | Nkeji 3 |
| NCT01455090 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Nọvemba 30, 2011 | Agba 2 |
| NCT03490097 | Mahadum Ain Shams | Ịba ọcha n'anya c | Ọrịa Metabolic | Disemba 1, 2017 | Agba 2 | Nkeji 3 |
| NCT01170962 | Bristol-Myers Squibb | Ọrịa ịba ọcha n'anya C | Ọgọst 2010 | Agba 2 |
| NCT02333292 | Hospitallọ ọgwụ Mahadum Valme | Hospitallọ ọgwụ del SAS de Jerez | Hospitallọ ọgwụ General Universitario Elche | Hospitallọ ọgwụ La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Hospital de Figueres | Hospitallọ ọgwụ Universitario Puerto Real Hospitallọ ọgwụ General Universitario de Alicante | Hospitallọ ọgwụ Universitario Araba | Hospitallọ ọgwụ Royo Vilanova | Hospitallọ ọgwụ Universitario de Burgos | Complejo Hospitalario Universitario de Huelva Navarra | Clinico Clinico Universitario San Cecilio | Hospitallọ ọgwụ Universitario La Fe | Hospitallọ Ọgwụ General Universitario de Valencia | Hospitallọ ọgwụ Universitario Infanta Leonor | Hospitallọ ọgwụ Universitario de Gran Canaria na Luz|Hospital General Universitario de Castellón|Hospital Parc Taulí, Sabadell | Ọrịa ịba ọcha n'anya C na-adịghị ala ala | Disemba 2014 |
|
| NCT03200184 | Tehran University of Medical Sciences | Ịba ọcha n'anya C | Septemba 1, 2016 | Agba 4 |
| NCT03188276 | Ụlọ ọgwụ mmekọ nke atọ, Mahadum Sun Yat-Sen | Ịba ọcha n'anya C | Febụwarị 1, 2016 | Agba mbụ 1 |
| NCT01830205 | Bristol-Myers Squibb | Ịba ọcha n'anya C | Septemba 2012 | Agba 1 |
Atụmatụ18Ọrụ nlebanya na-agbanwe agbanwe nke akwadoro4, na6A na-akwado ọrụ ngo.
Usoro njikwa ogo mba ụwa dị elu etinyela ntọala siri ike maka ire ahịa.
Nlekọta dị mma na-aga n'ihu na usoro ndụ nke ngwaahịa ahụ niile iji hụ na ịdịmma na mmetụta ọgwụgwọ.
Ndị otu Regulatory Affairs ndị ọkachamara na-akwado ịdịmma chọrọ n'oge ngwa na ndebanye aha.
Ahịrị nkwakọ ngwaahịa Korea Countec
Taiwan CVC ahịrị nkwakọ ngwaahịa
Line CAM Board Ịtali
Igwe na-akpakọrịta Fette German
Ihe nchọpụta mbadamba ihe ngosi nke Japan
Ụlọ njikwa DCS
Mmekọrịta mba ụwa
Imekọ ihe ọnụ n'ụlọ
Dee ozi gị ebe a ziga anyị ya
