Ndị na-emepụta China Doxycycline Hyclate na ndị na-ebubata ngwaahịa |CPF

Doxycycline Hyclate

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Aha API	Ngosipụta	Nkọwapụta	US DMF	EU DMF	CEP
Doxycycline Hyclate	Ọgwụ nje	USP/EP	13771	√

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Doxycycline hyclate bụ ọgwụ nje [1].

Doxycycline hyclate bụ ihe ewepụtara tetracycline ma nwee ọrụ nke mgbochi mkpali na antimicrobial.Doxycycline na-egbochi mmegharị nje dengue na vitro na-adabere na okpomọkụ.Uru IC50 bụ 52.3μM na 37°C na 26.7μM na 40°C.Ọ na-egbochi nje dengue site na igbochi NS2B-NS3 serine protease nke nje.60μM doxycycline na-ebelata CPE nke mkpụrụ ndụ nje DNEV2 [1].

A na-ahụta Doxycycline dị ka onye na-egbochi MMP.Ọgwụgwọ Doxycycline na-ebelata ọkwa MMP-8 na -9 ma gbochie nkwupụta anụ ahụ MMP-2 na MMP-9.Ọzọkwa, ọgwụgwọ na doxycycline nke ukwuu na-ebelata ihe omume nke intracranial aneurysms.A kọwokwa Doxycycline dị ka onye na-egbochi mkpali na-adabere na mgbochi ya nke matrix metalloproteinases.Tụkwasị na nke ahụ, doxycycline nwere ọrụ antimalarial siri ike na uru IC50 nke 320nM na 96h in vitro [2, 3].

Ntụaka:
[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Mmetụta mgbochi nke doxycycline megide nje virus dengue na vitro.Arch Virol.2014 Eprel; 159 (4): 711-8 .
[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Ọrụ nke matrix metalloproteinases (MMPs) na MMP inhibitors na intracranial aneurysms: akụkọ nyocha.Med J Islam Repub Iran.2013 Nov; 27 (4): 249-254 .
[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.In vitro na in vivo ọgwụ mgbochi ịba nke tetracyclines kachasị mma.Ndị nnọchi anya Antimicrob Chemother.2013 Jul; 57 (7): 3131-6 .

Nkọwa

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), ọgwụ nje, bụ ihe na-eme ihe na-arụ ọrụ ọnụ yana ihe mgbochi metalloproteinase (MMP) [1].

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NCT01935622	Mahadum Virginia Commonwealth	Ihe na-abụghị nke ischemic Cardiomyopathy\|Ọdịda obi Systolic (NYHA II-III)	Julaị 2012	Agba 2
NCT01886560	Mahadum Sun Yat-sen	Anya na-agba ọkụ	Septemba 2013	Agba 2 \| Nkeji 3
NCT04239755	Mahadum Damanhour \| Mahadum Tanta	Mmerụ ahụ nke Ụbụrụ	Disemba 15, 2019	Agba 4
NCT02204254	Ụlọ Ọgwụ Center Universitaire de Nice	Rosacea	Maachị 2014	Ọ metụtaghị
NCT00837213	Stiefel, ụlọ ọrụ GSK \| GlaxoSmithKline	Ihe otutu	Ọgọst 2007	Agba 4
NCT03115177	Rush University Medical Center	Osteoarthritis	Nọvemba 2015	Ọ metụtaghị
NCT03618108	Cadrock Pty. Ltd.\| Center for Digestive Diseases, Australia	Ọrịa obi obi \| Chlamydophila Pneumoniae ọrịa	Eprel 4, 2018	Agba 2
NCT03435952	MD Anderson Cancer Center \| BioMed Valley Discoveries, Inc\|Merck Sharp & Dohme Corp.	Malignant Neoplasm nke ara Saịtị\|Mgbochi Neoplasms nke egbugbere ọnụ Oral Cavity na pharynx\|Malignant Neoplasms nke nwoke Genital akụkụ	Julaị 10, 2018	Agba 1
NCT01867294	Ọmụmụ na Community Cancer Research United \| National Cancer Institute (NCI)	Neoplasm dị elu dị njọ \| Mgbagwoju anya akpụkpọ ahụ	Ọgọst 31, 2012	Agba 2
NCT01677286	Mahadum Boston	Amyloidosis	Julaị 2012	Agba 2
NCT00511875	Thomas Gardner \| Ndị na-ahụ maka ọrịa shuga na-eto eto \| Milton S. Hershey Medical Center	Ọrịa mamịrị retinopathy	Julaị 2008	Agba 2
NCT04108897	Mahadum Johns Hopkins	Rosacea	Septemba 17, 2019	Agba mbụ 1
NCT00631501	Mahadum Kaunas nke Medicine \| Hospitallọ Ọgwụ Mahadum, Linkoeping	Epicondylalgia n'azụ (Tennis Elbow)		Ọ metụtaghị
NCT02203682	Mahadum Sun Yat-sen	Graves Ophthalmopathy\|Ọrịa ili\|Ọrịa Anya\|Ọrịa Thyroid\| Ọrịa Sistemu Endocrine\| Ọrịa Anya, Ihe Nketa \| Hyperthyroidism\| Ọrịa Autoimmune	Julaị 2014	Agba 2
NCT02005653	Council Indian Medical Research	Filarial;Mgbochi	Febụwarị 2009	Agba 4
NCT03585140	Centro Dermatologico Dr. Ladislao de la Pascua	Acne Vulgaris \| Ngbanwe nri	Ọnwa Mbụ 1, 2016	Ọ metụtaghị
NCT02147262	Mahadum Medical Center Ljubljana \| Mahadum Ljubljana School of Medicine, Slovenia \| Medical University of Vienna \| Mahadum Harvard	Atrophic Acrodermatitis na-adịghị ala ala	Julaị 2013	Ọ metụtaghị
NCT02220751	Mahadum Sao Paulo \| Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontitis \| Ụdị 2 Ọrịa shuga mellitus	Maachị 2009	Nkeji 3
NCT01825408	Mahadum nke North Carolina, Chapel Hill	Sinusitis	Febụwarị 2013	Agba 4
NCT02884713	King Faisal Specialist Hospital & Research Center	GASTRITIS	Ọnwa Isii 2013	Ọ metụtaghị
NCT02726646	Mahadum Campinas, Brazil \| Pontificia Universidade Catolica de Sao Paulo	Periodontitis na-adịghị ala ala	Ọnwa Isii 2015	Agba 2
NCT00883818	Samsung Medical Center	eriri afọ na-emebiga ihe ókè	Jenụwarị 2007	Agba 4
NCT00829790	Teva Pharmaceuticals USA	Ahụ ike	Ọktoba 2006	Agba 1
NCT01949233	Mahadum Oxford \| Ụlọ Ọgwụ Mahadum Oxford NHS Trust	Ọrịa Marfan	Ọktoba 2013	Agba 2
NCT01518192	Ụlọ Ọrụ Ahụike Mahadum Ljubljana \| Agencylọ Ọrụ Nnyocha Slovenian	Erythema Migrans \| Mgbaàmà Ọrịa Ọrịa Lyme gachara	Ọnwa Isii 2006	Agba 4
NCT02845024	Mahadum Islamic Azad, Tehran	Ọrịa shuga mellitus na-arịa ọrịa Periodontal	Septemba 2014	Ọ metụtaghị
NCT01879930	Ụlọ ọgwụ University Inselspital, Berne	Ọrịa mgbu Pelvic na-adịghị ala ala\|Ọrịa mgbu nke eriri afo	Nọvemba 2012	Agba 4
NCT00041977	Ụlọ ọrụ CollaGenex Pharmaceuticals	Acne Rosacea	June 2002	Nkeji 3
NCT02341209	Rochester General Hospital	Ọrịa kansa T-cell Lymphoma \| Mycosis Fungoides \| Ọrịa Sezary	Febụwarị 6, 2018	Agba 2
NCT00002872	Eastern Cooperative Oncology Group\|National Cancer Institute (NCI)\|North Central Cancer Treatment Group	Ọrịa Metastatic	Nọvemba 1996	Nkeji 3
NCT03162497	Medical University nke Vienna	Ọrịa Anya Akọrọ \| Meibomian Gland adịghị arụ ọrụ	Ọnwa Mbụ 8, 2018	Agba 4
NCT01418742	Gesellschaft fur Medizinische Innovation ?Hamatologie und Onkologie mbH\|Clin Nyochaa GmbH	Colorectal Carcinoma	Ọgọst 2011	Agba 2
NCT00980148	Ụlọ ọrụ mba nke Allergy na Ọrịa na-efe efe (NIAID)	Ọrịa Chlamydial	Disemba 2009	Nkeji 3
NCT03342456	Ụlọ ọgwụ Xiangya nke atọ nke Central South University\|Livzon Pharmaceutical Group Inc.\|Yung Shin Pharm.Ụlọ ọrụ Ind. Co., Ltd.	Ulcer duodenal n'ihi Helicobacter Pylori	Disemba 13, 2017	Agba 4
NCT04310930	Mahadum nke Queensland \| Ngalaba Ahụike Ọchịchị Australia \| Ụlọ Ọgwụ Hospitallọ Ọgwụ ụmụaka \| Cystic Fibrosis Foundation \| Mahadum Newcastle \| Mahadum Griffith \| Erasmus Medical Center \| Mahadum Monash \| Mahadum Copenhagen \| Hospitallọ ọgwụ Cochin \| South Australian Health and Medical Research Institute \| Mahadum nke Melbourne \| Mahadum James Cook, Queensland, Australia \| Murdoch Children Research Institute	Ọrịa Pulmonary N'ihi Mycobacteria (Nchọpụta)	Maachị 2020	Agba 2 \| Nkeji 3
NCT03709459	Ụlọ ọrụ Kirby \| South Australian Health and Medical Research Institute \| Mahadum Monash	Mgbochi STIs	Disemba 17, 2019
NCT04067011	Emergent BioSolutions\|Ikikere Nchọpụta Na Mmepe Ọdịnihu	Anthrax	Ọgọst 12, 2019	Agba 2
NCT02844634	Ụlọ ọrụ British Columbia maka Nchịkwa Ọrịa	HIV \| syphilis	Mee 15, 2018	Agba 4
NCT00647959	Mylan Pharmaceuticals	Ahụ ike	Maachị 2006	Agba 1
NCT00170222	Medical Center Alkmaar	Ọrịa Pulmonary Na-egbochi Ahụ Ike	Julaị 2002	Agba 4
NCT03075891	Galderma	Rosacea	Julaị 5, 2017	Agba 4
NCT00031499	Ụlọ ọrụ mba nke Allergy na Ọrịa na-efe efe (NIAID)	Ọrịa syphilis	June 2000	Nkeji 3
NCT01205464	Mahadum Linkoeping	Ike ọgwụgwụ\|Mgbu na-egbuke egbuke	Febụwarị 2005	Ọ metụtaghị
NCT01301586	Akụkọ ihe mere eme nke Nexgen Dermatologics, Inc.	ACNE VULGARIS	Nọvemba 2010	Agba 1 \| Nkeji 2
NCT02305940	Ụlọ akwụkwọ Imperial College London	Ọrịa na-egbochi akpa ume na-adịghị ala ala (COPD)	Julaị 2014	Nkeji 3
NCT00351182	Dong-Min Kim \| Ụlọ Ọgwụ Mahadum Chosun	Ikpochapụ Typhus	Septemba 2005	Nkeji 3
NCT03334682	Ụlọ ọgwụ Mahadum Nantes	Acne vulgaris	Ọnwa Mbụ 31, 2018	Nkeji 3
NCT01788215	Mahadum nke Rochester	Polycystic Ovarian Syndrome (PCOS) \| Oge nsọ nsọ oge niile \| Androgen ngafe	Nọvemba 2010	Nkeji 3
NCT03076281	Sidney Kimmel Cancer Center na Mahadum Thomas Jefferson \| Mahadum Thomas Jefferson	Larynx \| LIP \| oghere ọnụ \| pharynx	Eprel 3, 2017	Agba 2
NCT00439166	Hamilton Health Sciences Corporation \| The Physicians' Services Incorporated Foundation \| Mahadum McMaster	Ọrịa Alzheimer	Febụwarị 2007	Nkeji 3
NCT02463942	Mahadum Medical Center Ljubljana \| Mahadum nke Ljubljana School of Medicine, Slovenia	Encephalitis na-ebute akọrọ	Septemba 2014	Ọ metụtaghị
NCT00803842	Mahadum Northwwest	Ọrịa cancer akpa ume na-abụghị obere cell	Ọktoba 2008	Ọ metụtaghị
NCT02086591	Mahadum nke Rochester	Ndị okenye na-agbasa nnukwu B-cell Lymphoma \| Mantle Cell Lymphoma Na-agaghachi \| Lymphoma, Follicular \| Mpaghara Marginal B-Cell Lymphoma	Maachị 2014	Agba 2
NCT03980223	Mahadum California, San Francisco \| Mahadum Washington \| National Institute of Allergy and Diseases (NIAID) \| Mayne Pharma International Pty Ltd \| Ngalaba Ahụike Ọha na San Francisco	Gonorrhea \| Chlamydia \| Syphilis	Nọvemba 26, 2019	Agba 4
NCT00355459	Mahadum Texas Southwwest Medical Center	Ọrịa Anya Akọrọ	Ọgọst 2005	Ọ metụtaghị
NCT01254799	Omar Mamdouh Shaaban \| Mahadum Assiut	Uterine Hemorrhage	Jenụwarị 2008	Nkeji 3
NCT01547325	NanoSHIFT LLC \| Ngalaba nchekwa nke United States	Ọnya ịwa ahụ agbapụrụ	Mee 2012	Ọ metụtaghị
NCT00653380	Par Pharmaceutical, Inc.\|Anapharm	Iji chọpụta bioequivalence n'okpuru ọnọdụ ibu ọnụ	Septemba 1999	Agba 1
NCT00635609	Warner Chilcott	Acne vulgaris	Maachị 2008	Agba 4
NCT03765931	Institut de Recherche pour le Development	Ahụ ọkụ	Julaị 2016	Agba 4
NCT01160640	Harold Wiesenfeld \| National Institute of Allergy and Diseases Diseases (NIAID) \| Mahadum Pittsburgh	Ọrịa na-efe efe pelvic	Nọvemba 2010	Agba 2
NCT01756833	Mahadum nke Maryland, Baltimore \| National Institute on Aging (NIA)	Aneurysm	Mee 2013	Agba 2
NCT00688064	Galderma	Acne vulgaris siri ike	Ọgọst 2008	Nkeji 3
NCT01320033	Galderma	Acne vulgaris	Maachị 29, 2011	Agba 2
NCT03397004	St. Michael's Hospital, Toronto \| Barrow Neurological Institute \| Mahadum Duke \| Ụlọ ọrụ Feinstein maka nyocha ahụike \| Mahadum Pittsburgh \| Sunnybrook Health Sciences Center	Telangiectasia Hemorrhagic Hemorrhagic (HHT)	Septemba 12, 2018	Agba 2
NCT01635530	Ụlọ ọgwụ Mahadum Turku	Neuroborreliosis Lyme	Ọgọst 2012	Agba 4
NCT03727620	Mahadum Mohammed V Souissi	Periodontitis na-eme ihe ike	Ọnwa Mbụ 6, 2014	Agba 1 \| Nkeji 2
NCT02688738	Ụlọ ọrụ Rothman Orthopedics	Propionibacteria	Maachị 2015	Ọ metụtaghị
NCT00358462	Mahadum Washington \| National Institute of Allergy and Diseases (NIAID)	Urethritis	Jenụwarị 2007	Nkeji 3
NCT02864550	Ụlọ ọrụ British Columbia maka Nchịkwa Ọrịa	Ọrịa syphilis \| Ọrịa na-ebute site ná mmekọahụ	Ọgọst 15, 2019	Agba 4
NCT01595594	Mahadum Sao Paulo \| Fundação de Amparo à Pesquisa do Estado de São Paulo	Ọrịa Periodontal \| Ụdị ọrịa shuga 2	Maachị 2010	Nkeji 3
NCT00964834	PharmAthene, Inc.\| Ụlọ Ọrụ Na-ahụ Maka Ahụ Ike Mba (NIH)\|Medarex\|Quintiles, Inc.	Anthrax	Julaị 2009	Agba 1
NCT01809444	Mahadum Sun Yat-sen	Ọrịa anya Associated Thyroid	Nọvemba 2012	Agba 2 \| Nkeji 3
NCT01590082	MD Anderson Cancer Center \| National Institute of Health (NIH) \| National Cancer Institute (NCI)	Melanoma	Nọvemba 2012	Agba 1 \| Nkeji 2
NCT00207584	Ụlọ ọrụ maka Nchịkwa na Mgbochi Ọrịa	Mycoplasma pneumoniae	Jenụwarị 1994	Ọ metụtaghị
NCT00775177	Ụgwọ nke ụlọ ọrụ Ranbaxy Laboratories Limited\|Ranbaxy Inc.	Ahụ ike	Ọnwa Isii 2005	Ọ metụtaghị
NCT03462329	Mahadum Medical Center Ljubljana	Erythema Migrans	Ọnwa Isii 1, 2018	Ọ metụtaghị
NCT00000403	Mahadum Indiana \| National Institute of Arthritis na Musculoskeletal na Skin Diseases (NIAMS) \| National Institute on Aging (NIA)	Osteoarthritis	Septemba 1996	Nkeji 3
NCT03508232	Mahadum nke Alberta \| Royal Alexandra Hospital	Nkeji ST Elevation Myocardial Infarction\| Obi ada ada	Jenụwarị 6, 2020	Agba 2
NCT02553473	Ụlọ ọgwụ Sorlandet HF	Neuroborreliosis, Borrelia Burgdorferi	Ọktoba 2015	Nkeji 3
NCT02207556	Medical College nke Wisconsin	Amyloidosis nke sistemu nke mbụ	Ọktoba 1, 2014	Agba 2
NCT01783106	Hospitallọ ọgwụ Mahadum Royal Liverpool \| National Association for Colitis and Crohn's Disease \| National Institute for Health Research, United Kingdom	Ọrịa Crohn	Ọnwa Abụọ 1, 2014	Agba 2
NCT00353743	Hospitallọ ọgwụ de Clinicas de Porto Alegre	Ime ime, septic	Mee 2006	Ọ metụtaghị
NCT01727973	Mahadum Sun Yat-sen	Graves Ophthalmopathy\|Ọrịa ili\|Ọrịa Anya\|Ọrịa Thyroid\| Ọrịa Sistemu Endocrine\| Ọrịa Anya, Ihe Nketa \| Hyperthyroidism\| Ọrịa Autoimmune	Ọktoba 2012	Agba 1 \| Nkeji 2
NCT00857038	Medical Center Alkmaar\|Leiden University Medical Center \| Mahadum Amsterdam	Ọrịa na-egbochi akpa ume na-adịghị ala ala\|Mfụfụ\| Emphysema	Eprel 2009	Agba 4
NCT02774993	Ụlọ Ọgwụ Mahadum Mba, Singapore \| Ụlọ Ọgwụ Tan Tock Seng \| Mahadum Mba, Singapore \| A * Star	Ụkwara nta	Septemba 2015	Agba 2
NCT03474458	IRCCS Policlinico S. Matteo	Obi AL Amyloidosis	Febụwarị 11, 2019	Agba 2 \| Nkeji 3
NCT02874430	Sidney Kimmel Cancer Center na Mahadum Thomas Jefferson \| Mahadum Thomas Jefferson	Carcinoma ara	Ọnwa Isii 8, 2016	Agba 2
NCT00016835	Mahadum nke Michigan \| National Institute of Dental and Craniofacial Research (NIDCR)	Ọrịa Periodontal \| Ọrịa shuga mellitus, ụdị 2	Ọktoba 17, 2001	Agba 2
NCT00064766	Eunice Kennedy Shriver National Institute of Health Child and Human Development (NICHD)	Ọbara ọgbụgba endometrial \| Ọrịa oge	Febụwarị 2003	Agba 4
NCT00803452	Mahadum Louisville	Blepharitis	Julaị 2008	Agba 4
NCT01434173	Bayer\|RTI Health Solution	Mmerụ imeju nke ọgwụ butere	Julaị 2001
NCT00126204	Ụlọ ọgwụ Barnes-Juu	Aortic Aneurysm	Maachị 2004	Ọ metụtaghị
NCT01917721	Ahụike Hawaii Pacific	Ọrịa Kawasaki\|Ọrịa Aneurysm	Ọktoba 2013	Agba 2
NCT02775695	Medical College nke Wisconsin	Ọrịa cancer pancreatic na-agbanwe agbanwe	Eprel 3, 2017	Agba 2
NCT03824340	Ụlọ ọgwụ Aljazeera	Amụghị nwa	Jenụwarị 30, 2019	Ọ metụtaghị
NCT01847976	Ụlọ nyocha ụlọ ọgwụ Ottawa \| Canadian Breast Cancer Foundation	Mgbu	Ọgọst 2013	Agba 2
NCT02850913	Mahadum Makerere \| Mahadum Oxford	Ihe ọdịdọ	Septemba 5, 2016	Agba 2
NCT00764361	Ụlọ ọrụ NanoSHIFT LLC	Ọrịa mamịrị Ụkwụ Ọnya	Jenụwarị 2009	Agba 2
NCT02036528	Ụlọ ọrụ Royer Biomedical, Inc.	Ọrịa mamịrị Ụkwụ	Jenụwarị 2014	Agba 1 \| Nkeji 2
NCT01661985	Ostergotland County Council, Sweden\|Statens Serum Institut	Urethritis \| Cervicitis \| Ọrịa Mycoplasma Genital \| Chlamydia Trachomatis	Febụwarị 2010	Agba 4
NCT01380483	Par Pharmaceutical, Inc.\|Anapharm	Iji chọpụta bioequivalence n'okpuru ọnọdụ ibu ọnụ	Jenụwarị 2000	Agba 1
NCT00648180	Mylan Pharmaceuticals	Ahụ ike	Julaị 2005	Agba 1
NCT01426269	Galderma Laboratories, LP	Rosacea	Septemba 2011	Agba 4
NCT02753426	Mahadum California, San Francisco	Ọrịa akụrụ na-adịghị ala ala \| Ọrịa obi	Eprel 2016	Agba 1
NCT02583282	Postgraduate Institute of Medical Education na Research	Mfụfụ nke Pleural	Ọgọst 1, 2015	Ọ metụtaghị
NCT02927496	Task Force for Global Health\|United States Agency for International Development (USAID)	Lymphedema \| Lymphatic Filariasis \| Filariasis	Ọnwa Isii 19, 2018	Nkeji 3
NCT00652795	Par Pharmaceutical, Inc.\|Anapharm	Iji chọpụta bioequivalence n'okpuru ọnọdụ ibu ọnụ	Julaị 2004	Agba 1
NCT03956212	Mahadum Medical Center Ljubljana \| Mahadum nke Ljubljana School of Medicine, Slovenia	Erythema Migrans	Ọnwa Isii 1, 2017	Ọ metụtaghị
NCT00855595	Bayer	Papulopustular rosacea	Febụwarị 2009	Agba 4
NCT03457636	Derm Research, PLLC	Ihe otutu	Maachị 19, 2018	Agba 4
NCT02894268	Ụlọ ọgwụ Sir Run Run Shaw	Ọrịa Helicobacter Pylori	Febụwarị 2016	Agba 4
NCT03465774	MD Anderson Cancer Center \| National Cancer Institute (NCI)	Mfụfụ nke Pleural	Maachị 8, 2018	Agba mbụ 1