Pomalidomide

Nkọwa dị mkpirikpi:

Aha API Ngosipụta Onye mmepụta ihe Ụbọchị Mmebi Ikikere (US)
Pomalidomide Ọgwụ Oncology Celgene  

 


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Nkọwa ngwaahịa

Pomalidomide, nke a na-akpọbu CC-4047 ma ọ bụ actimid, bụ mkpụrụ ndụ immunomodulatory siri ike nke na-egosipụta ọrụ antineoplastic maka ọgwụgwọ nke ọrịa hematological, karịsịa nlọghachi azụ na refractory multiple myeloma (MM). Dị ka ihe sitere na thalidomide, pomalidomide nwere usoro kemịkalụ yiri nke ahụ dị ka thalidomide ma e wezụga mgbakwunye nke otu oxo abụọ na mgbanaka phthaloyl na otu amino na ọnọdụ nke anọ. N'ozuzu, dị ka molekul immunomodulatory, pomalidomide na-egosipụta ọrụ antitumor site na usoro nke igbochi microenvironment tumor site na mgbanwe nke cytokines na-akwado tumor (TNF-α, IL-6, IL-8 na VEGF), na-achịkwa ọrụ ndị dị mkpa nke ụbụrụ. sel, yana nkwado sitere na sel ndị ọbịa na-enweghị mgbochi.

A na-eji Pomalidomide agwọ ọtụtụ myeloma (cancer nke sitere na ọrịa ọbara na-aga n'ihu). A na-enyekarị Pomalidomide ma ọ dịkarịa ala ọgwụ abụọ ọzọ a nwalere na-enweghị ihe ịga nke ọma.

A na-ejikwa Pomalidomide agwọ ọrịa Kaposi sarcoma metụtara AIDS mgbe ọgwụ ndị ọzọ anaghị arụ ọrụ ma ọ bụ kwụsị ọrụ. A pụkwara iji pomalidomide na-agwọ Kaposi Sarcoma na ndị okenye bụ ndịHIV-adịghị mma.

Pomalidomide dị naanị site na ụlọ ahịa ọgwụ enwetara ikike n'okpuru mmemme pụrụ iche. Ị ga-edebanye aha na mmemme ma kwenye ijimgbochi ịmụ nwajikoro dị ka achọrọ.

Enwere ike iji Pomalidomide maka ebumnuche edepụtaghị na ntuziaka ọgwụ a.

Pomalidomide nwere ike ịkpata nkwarụ ọmụmụ siri ike, nke na-eyi ndụ egwu ma ọ bụ ọnwụ nke nwa ọhụrụ ma ọ bụrụ na nne ma ọ bụ nna na-aṅụ pomalidomide n'oge a tụrụ ime ma ọ bụ n'oge ime ime. Ọbụna otu dose nke pomalidomide nwere ike ịkpata nnukwu ntụpọ nke ogwe aka na ụkwụ, ọkpụkpụ, ntị, anya, ihu, na obi nwa. Ejila pomalidomide ma ọ bụrụ na ị dị ime. Gwa dọkịta gị ozugbo ma ọ bụrụ na oge oge gị agwụla mgbe ị na-ewere pomalidomide.

Asambodo

2018 GMP-2
原料药GMP证书201811 (captopril, thalidomide wdg)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
Akwụkwọ ozi FDA-EIR-201901

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