ndabere

Tofacitinib citrate, nke a makwaara dị ka CP-690550 citrate, bụ onye na-egbochi ike nke janus kinase 3 (JAK3), tyrosine kinase na-egbochi hematopoetic cell na-etinye aka na ntụgharị mgbaàmà na-achịkwa ndụ lymphocyte, mmụba, ọdịiche, na apoptosis. Mgbochi ahụ bụ JAK3 kpọmkwem yana nhọrọ 1000-fold karịa ihe ndị ọzọ na-abụghị JAK ezinụlọ kinases. E wezụga igbochi JAKS (IC50 = 1 nM), tofacitinib citrate na-egbochikwa janus kinase 2 (JAK2) na janus kinase 1 (JAK1) na 20- na 100-fold obere ike n'otu n'otu. Otú ọ dị, n'ime nnyocha e mere n'oge na-adịbeghị anya, a kọrọ na njikọ njikọ (Ki) nke tofacitinib citrate kwupụta JAK1, JAK2, na JAK3 bụ 1.6 nM, 21.7 nM, na 6.5 nM n'otu n'otu.

Ntụaka

Lalitha Vijayakrishnan, R. Venkataramanan na Palak Gulati. Na-emeso mbufụt na janus kinase inhibitor CP-690,550. Ọnọdụ na sayensị ọgwụ ọgwụ 2011: 32 (1); 25-34

Ndepụta ngwaahịa

• 1. Panagi I, Jennings E, et al. "Salmonella Effector SteE na-atụgharị Serine Mammalian/Treonine Kinase GSK3 n'ime Tyrosine Kinase ka ọ bụrụ Direct Macrophage Polarization." Cell Host Microbe. 2020;27 (1):41–53.e6. PMID: 31862381
• 2. McInnes IB, Byers NL, et al. "Ntụle nke baricitinib, upadacitinib, na tofacitinib na-emezigharị ụkpụrụ nke cytokine na-egosi na ụmụ mmadụ leukocyte subpopulations." Ọrịa ogbu na nkwonkwo Res Ther. 2019 Ọgọst 2;21 (1): 183 . PMID: 31375130
• 3. Liu S, Verma M, et al. "Steroid na-eguzogide ụdị 2 mkpụrụ ndụ lymphoid innate sitere na ndị ọrịa nwere ụkwara ume ọkụ siri ike: Ọrụ nke thymic stromal lymphopoietin." J Allergy Clin Immunol. 2018 Jan; 141 (1): 257-268.e6 . PMID: 28433687
• 4. Zheng, Lufeng, et al. "3′ UTR nke pseudogene CYP4Z2P na-akwalite angiogenesis tumor na ọrịa ara ara site na ime ihe dị ka ceRNA maka CYP4Z1." Nnyocha na ọgwụgwọ ọrịa kansa ara (2015): 1-14. PMID: 25701119

Nkọwa

Tofacitinib citrate bụ onye na-emechi ọnụ JAK1/2/3 nwere IC50s nke 1, 20, na 112 nM, n'otu n'otu. Tofacitinib citrate nwere antibacterial, antifungal na antiviral ọrụ.

Nchekwa

4ºC, chebe pụọ na ìhè

* Na ihe mgbaze: -80 ° C, ọnwa 6; -20C, ọnwa 1 (chebe ọkụ)

Ọdịdị chemical

Data bayoloji emetụtara

Data bayoloji emetụtara

Data bayoloji emetụtara

Data bayoloji emetụtara

Data bayoloji emetụtara