Nkọwa

Sugammadex sodium bụ ihe nrụpụta γ-cyclodextrin sịntetik, ma na-eme dị ka ihe ngbanwe ọhụrụ maka ngọngọ neuromuscular.

Aha mkpokọta: sugammadex (soo GAM ma dex)
Aha ika: Bridion

Sugammadex na-atụgharị mmetụta nke ụfọdụ ọgwụ a na-enye n'oge usoro ịwa ahụ iji mee ka ahụ gị dị jụụ.

A na-eji Sugammadex na njedebe nke ịwa ahụ, iji nyere aka weghachite ọrụ anụ ahụ nke ọgwụ ndị ọzọ gbochiri n'oge ịwa ahụ.

Enwere ike iji Sugammadex maka ebumnuche edepụtaghị na ntuziaka ọgwụ a.

A na-eji ya weghachi mmetụta nke ọgwụ ụfọdụ.

Na Vivo

Ịgba ọgwụ sugammadex enweghị mmetụta dị ịrịba ama na ọbara mgbali elu ma ọ bụ ọnụọgụ obi.Mgbe ịgba ọgwụ mgbochi rocuronium dị elu, mgbake 90% nke usoro ụgbọ oloko-nke anọ na-ewe 28 min (SD 7 min) mgbe saline gasịrị, 26 min (SD 9.5 min) mgbe 1 mg/kg sugammadex, na 8 min (SD). 3.6 min) mgbe 2.5 mg/kg summadex [1].Sugammadex na-ebute ngbanwe ngwa ngwa na zuru oke nke mgbochi neuromuscular nke rocuronium kpatara.Oge mgbake iji zụọ nke ruru anọ = 0.9 mgbe mgbake na mberede bụ 14.4 min (SD = 3.4 min; n = 14).Nke a na-ebelata nke ukwuu ruo 3.7 min (SD = 3.3 min; n = 4) na summadex 0.5 mg / kg na 1.9 min (SD = 1.0 min; n = 4) na summadex 1.0 mg / kg [2].Atụmatụ ọkara ndụ sugammadex na enwe Rhesus bụ 30 (SEM=4.9) min[3].

Nchekwa

Ọdịdị chemical