Vericiguat

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Aha API Ngosipụta Onye mmepụta ihe Ụbọchị Mmebi Ikikere (US)
Vericiguat Obi mgbawa Bayer na MSD Mee. Ọktoba 24, 2031


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Nkọwa ngwaahịa

Vericiguat bụ apyrazolopyridineya bu5-fluoro-1H-pyrazolo [3,4-b] pyridinenke amino hydrogen nọ n'ọkwa 1 jiri otu 2-fluorobenzyl dochie ya nahydrogenn'ọnọdụ 3 ka 4,6-diamino-5-[(methoxycarbonyl) amino] pyrimidin-2-yl nọchiri anya ya. Ọ bụ ihe solubleguanylatecyclase stimulator nke a na-eji agwọ ọrịa obi na-adịghị ala ala. Ọ nwere ọrụ dị ka solubleguanylatecyclase activator, onye nnọchi anya vasodilator na onye nnọchi anya antihypertensive. Ọ bụ otuaminopyrimidine, apyrazolopyridine, ester carbamate na ogige organofluorine.

A na-enyocha Vericiguat na nnwale ụlọ ọgwụ NCT02861534 (Ọmụmụ Vericiguat na ndị sonyere na nkụda mmụọ obi na mbelata ejection Fraction (HFrEF) (MK-1242-001)).

Vericiguat bụ SolubleGuanylateCyclase Stimulator. Usoro nke vericiguat dị ka aGuanylateCyclase Stimulator.

Vericiguat bụ ọgwụ eji ejikwa ma na-agwọ nkụda obi site na iji obere mbelata ejection (HFrEF). Ọ bara uru maka ọdịda obi na-akawanye njọ nke na-adịghị ala ala, nkụda mmụọ nke decompensated na nso nso a. Vericiguat anaghị agbatị ndụ mana ọ na-egbochi ibugharị ụlọ ọgwụ. Omume a na-akọwapụta ihe ngosi, usoro omume, dose, na usoro nchịkwa nke ndị otu ọkachamara, mmetụta ọjọọ, contraindications, na ọtụtụ ule iji kwado ihe akaebe nke uru ọgwụ na HFrEF.

Asambodo

2018 GMP-2
原料药GMP证书201811 (captopril, thalidomide wdg)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
Akwụkwọ ozi FDA-EIR-201901

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