Vericiguat
Vericiguat bụ apyrazolopyridineya bu5-fluoro-1H-pyrazolo [3,4-b] pyridinenke amino hydrogen nọ n'ọkwa 1 jiri otu 2-fluorobenzyl dochie ya nahydrogenn'ọnọdụ 3 ka 4,6-diamino-5-[(methoxycarbonyl) amino] pyrimidin-2-yl nọchiri anya ya. Ọ bụ ihe solubleguanylatecyclase stimulator nke a na-eji agwọ ọrịa obi na-adịghị ala ala. Ọ nwere ọrụ dị ka solubleguanylatecyclase activator, onye nnọchi anya vasodilator na onye nnọchi anya antihypertensive. Ọ bụ otuaminopyrimidine, apyrazolopyridine, ester carbamate na ogige organofluorine.
A na-enyocha Vericiguat na nnwale ụlọ ọgwụ NCT02861534 (Ọmụmụ Vericiguat na ndị sonyere na nkụda mmụọ obi na mbelata ejection Fraction (HFrEF) (MK-1242-001)).
Vericiguat bụ SolubleGuanylateCyclase Stimulator. Usoro nke vericiguat dị ka aGuanylateCyclase Stimulator.
Vericiguat bụ ọgwụ eji ejikwa ma na-agwọ nkụda obi site na iji obere mbelata ejection (HFrEF). Ọ bara uru maka ọdịda obi na-akawanye njọ nke na-adịghị ala ala, nkụda mmụọ nke decompensated na nso nso a. Vericiguat anaghị agbatị ndụ mana ọ na-egbochi ibugharị ụlọ ọgwụ. Omume a na-akọwapụta ihe ngosi, usoro omume, dose, na usoro nchịkwa nke ndị otu ọkachamara, mmetụta ọjọọ, contraindications, na ọtụtụ ule iji kwado ihe akaebe nke uru ọgwụ na HFrEF.





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