Sacubitril Hemicalcium

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沙库比曲半钙盐 Sacubitril Hemicalcium 1369773-39-6 N'ime ụlọ
沙库比曲钠盐 149690-05-1 N'ime ụlọ
LCZ-4 1426129-50-1 N'ime ụlọ
LCZ-7 1012341-48-8 N'ime ụlọ
LCZ-8 1012341-50-2 N'ime ụlọ
LCZ-9 149690-12-0 N'ime ụlọ

 

ndabere

AHU-377 hemicalcium nnu bụ nnu hemicalcium nke AHU-377.Ọ bụ ihe mgbochi nke neprilysin nwere uru IC50 nke 5 nM [1].

AHU-377 na angiotensin II AT1 antagonist valsartan dere LCZ696 na nha 1: 1 molar.LCZ696 bụ angiotensin receptor neprilysin inhibitor.Ọ nwere ike ibelata ọbara mgbali ma bụrụkwa ọgwụ ọhụrụ maka ọgwụgwọ nkụda obi.AHU-377 bụ pro-ọgwụ, ọ nwere ike gbanwee site enzymatic cleavage nke ethyl ester n'ime arụ ọrụ ụdị LBQ657.A na-akọ na AHU-377 (30 na 100 mg / kg, PO) nwere ike ịkpata mmetụta antihypertensive n'ụzọ dabere na dose na oke DAHI-SS.Ma na DOCA-nnu hypertensive oke, ọ na-egosi mbelata adịghị ike [2, 3].

Ntụaka:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide inhibitors endopeptidase inhibitors.J Med Chem.1995 Mee 12;38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Ọrụ nwere ike nke valsartan + AHU377 (LCZ696) na ọgwụgwọ nke nkụda obi.Echiche ndị ọkachamara nyocha ọgwụ.2013 Ọgọst; 22 (8): 1041-7 .
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al.Ntụnyere arụmọrụ nke AHU-377, onye na-egbochi neprilysin dị ike, n'ụdị oke abụọ nke ọbara mgbali elu dabere na olu.BMC Pharmacology 2011, 11 (Nkwadebe 1):P33.

Ọdịdị chemical

Sacubitril Hemicalcium

Asambodo

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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